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ea0029p10 | Adrenal cortex | ICEECE2012

The mTOR-pathway in normal and tumoral human adrenocortical tissues

De Martino M. , van Koetsveld P. , Feelders R. , Sprij-Mooij D. , Waaijers M. , Lamberts S. , de Herder W. , Colao A. , de Krijger R. , Pivonello R. , Hofland L.

Background: Novel treatment options are required for patients with adrenocortical carcinomas (ACCs). mTOR-inhibitors are anti-neoplastic drugs that target the mTOR-pathway.Aim: To describe the expression of the mTOR-pathway in normal and pathological adrenocortical tissues.Methods: We evaluated mRNA expression levels of mTOR, S6K and 4EBP1 in 10 normal adrenals (NA), 11 adrenal hyperplasias (AH), 19 adrenal adenomas (ACA) and 26 AC...

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ea0026p363 | Adrenal medulla | ECE2011

Expression of IGF/mTOR pathway components in human pheochromocytomas and in vitro inhibition of PC12 rat pheochromocytoma cell growth by mTOR inhibitors

De Martino M C , Feelders R A , van Koetsveld P M , De Krijger R R , Janssen J A M J L , Sprij-Mooij D , Lamberts S W J , de Herder W W , Colao Annamaria , Pivonello Rosario , Hofland Leo

The pathogenesis of pheochromocytomas (pheo) is poorly understood and malignant pheo need new treatment options. mTOR inhibitors, as sirolimus (S) and everolimus (E), are new promising antineoplastic drugs.Aim: To evaluate whether the IGF/mTOR pathways have a role in the pathogenesis and whether S and E may have antiproliferative effects in pheo.In 24 human pheo and two normal adrenal medulla (NM), we evaluated the mRNA expression ...

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Endocrine Abstracts

The mTOR-pathway in normal and tumoral human adrenocortical tissues

Expression of IGF/mTOR pathway components in human pheochromocytomas and in vitro inhibition of PC12 rat pheochromocytoma cell growth by mTOR inhibitors

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